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This household incorporates just one protein, SET7/9, which mono-methylates histone at H3K4 92 KMT7 was discovered to methylate, apart from histone, numerous non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and elements of the TATA binding protein (TBP) complex, TBP-associated factors TAF10 and TAF7 ninety three The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (target lysine is daring), can also be recognized by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of those substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a traditional mannequin for dynamic lysine methylation of both histone and non-histone proteins.
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